منابع مشابه
Xenotransplantation and tolerance.
Donor organ availability has become a major limiting factor in the progress of allotransplantation. This, and advances in genetic engineering in pigs, have led to increasing interest in the use of xenogeneic organs. In view of the greater difficulty encountered in overcoming immune responses to xenografts than to allografts, the success of clinical xenotransplantation may depend on finding ways...
متن کاملXenotransplantation — will tolerance be essential ?
kidney disease (CKD) adds to their prognostic evaluation in terms of mortality. They conclude that the determination of inflammatory markers is not helpful if age and comorbidity are taken into account. It would, however, be appropriate if some further analyses were performed before such a conclusion is advanced. The conclusion of Caravaca et al. [1] is based on a multivariate Cox-regression an...
متن کاملCarbohydrates in xenotransplantation
The success of allotransplantation has led to an increasing shortage of human organs from deceased donors. This crisis could be resolved by the use of organs from an anatomically suitable animal, such as the pig. The pig and human have, however, been evolving differently for approximately 80 million years, and numerous immunological and physiological barriers have developed that need to be over...
متن کاملImmunodepletion in xenotransplantation.
Xenograft transplantation is perhaps the most immunologically difficult problem in transplantation today. An overwhelming hyperacute rejection reaction (HAR) occurs within minutes of organ implantation. Preformed antibodies are thought to initiate this process. We used a pig-to-dog renal xenograft transplant model and investigated methods of decreasing the severity of hyperacute rejection. Fema...
متن کاملClinical xenotransplantation.
Two baboon liver xenografts transplanted to patients with B virus hepatitis supported life for 70 and 26 days but did not function optimally despite minimum or no histopathologic findings of overt humoral or cellular rejection in serial biopsies. However, there was evidence of complement activation in both cases, which in retrospect was thought to explain the unsatisfactory outcome. Strategies ...
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ژورنال
عنوان ژورنال: Current Opinion in Organ Transplantation
سال: 2017
ISSN: 1087-2418
DOI: 10.1097/mot.0000000000000466